Research

Main Content

2022 Publications

  • Badmus OO, Hillhouse SA, Anderson CD, Hinds TD, Stec DE. Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways. Clin Sci (Lond). 2022 Sep 30;136(18):1347-1366. doi: 10.1042/CS20220572. PMID: 36148775; PMCID: PMC9508552.
  • Bakrania BA, Palei AC, Bhattarai U, Chen Y, Granger, JP, Shahul S. Sustained elevated circulating activin a impairs global longitudinal strain in pregnant rats: a potential mechanism for preeclampsia-related cardiac dysfunction. Cells. 2022 Feb 21;11(4):742. doi: 10.3390-cells11040742. PMID: 35203391
  • Bakrania BA, George EM, Granger JP. Animal models of preeclampsia: investigating pathophysiology and therapeutic targets. Am J Obstet Gynecol. 2022 Feb;226(2S):S973-S987. doi: 10.1016/j.ajog.2020.10.025. PMID: 33722383
  • Bentz AB, Empson TA, George EM, Rusch DB, Buechlein A, Rosvall KA. How experimental competition changes ovarian gene activity in free-living birds: implications for steroidogenesis, maternal effects, and beyond. Horm Behav. 2022 Jun;142:105171. doi: 10.1016/j.yhbeh.2022.105171. Epub 2022 Apr 2. PMID: 35381449.
  • Bochi APG, Ferreira GDS, Del Bianco V, Pinto PR, Rodrigues LG, Trevisani MDS, Furukawa LNS, Bispo KCS, da Silva AA, Velosa APP, Nakandakare ER, Machado UF, Teodoro WPR, Passarelli M, Catanozi S. Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice. Antioxidants (Basel). 2022 Oct 13;11(10):2023. doi: 10.3390/antiox11102023. PMID: 36290746; PMCID: PMC9598599.
  • Chade AR and Bidwell GL. Novel drug delivery technologies and targets for renal disease. Hypertension. 2022 Jun 2;101161HYPERTENSIONAHA12217944.
  • Chatre L, Ducat A, Spradley FT, Palei AC, Chéreau C, Couderc B, Thomas KC, Wilson AR, Amaral LM, Gaillard I, Méhats C, Lagoutte I, Jacques S, Miralles F, Batteux F, Granger JP, Ricchetti M, Vaiman D. Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences. Redox Biol. 2022 Jul 30;55:102406. doi: 10.1016/j.redox.2022.102406. Epub ahead of print. PMID: 35964341; PMCID: PMC9389306.
  • Clemmer, JS, Hillegass WB, Taylor EB. Antihypertensice effects of immunosuppressive therapy in autoimmune disease. J Hum Hypertens. 2022 Apr 8. doi: 10.1038/s41371-022-00682-0. PMID: 35396536
  • Clemmer JS, Pruett WA. Modeling the physiological roles of the heart and kidney in heart failure with preserved ejection fraction during baroreflex activation therapy. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H597-H607. doi: 10.1152/ajpheart.00329.2022. Epub 2022 Aug 19. PMID: 35984764; PMCID: PMC9467477.
  • Clemmer JS, Shafi T, Obi Y. Physiological mechanisms of hypertension and cardiovascular disease in end-stage kidney disease. Curr Hypertens Rep. 2022 Oct;24(10):413-424. doi: 10.1007/s11906-022-01203-7. Epub 2022 Jun 16. PMID: 35708820.
  • da Silva AA, Moak SP, Dai X, Borges GC, Omoto ACM, Wang Z, Li X, Mouton AJ, Hall JE, do Carmo JM. Parental obesity alters offspring blood pressure regulation and cardiovascular responses to stress: role of P2X7R and sex differences. Am J Physiol Regul Integr Comp Physiol. 2022 May 1;322(5):R421-R433. doi: 10.1152/ajpregu.00300.2021. Epub 2022 Mar 23. PMID: 35318854
  • Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, Hall ME, Correa A, Hernandez AF, Golden SH, Menta RJ, Bertoni AG.  Dysglycemia and incident heart failure among blacks: the jackson heart study. Am Heart J. 2022 Mar;245:1-0. doi: 10.1016/j.ahj.2021.11.003. PMID: 34808103
  • Farahani RA, Yu S, Ferguson CM, Zhu YX, Tang H, Jordan KL, Saadiq IM, Chade AR, Lerman A, Lerman LO, Eirin A. Renal revascularization attenuates myocardial mitochondrial damage and improves diastolic function in pigs with metabolic syndrome and renovascular hypertension. J Cardiovasc Transl Res. 2022 Feb;15(1):15-26. doi: 10.1007/s12265-021-10155-3. Epub 2021 Jul 16. 
  • Gao J, Lei T, Wang H, Luo K, Wang Y, Cui B, Yu Z, Hu X, Zhang F, Chen Y, Ding W, Lu Z. Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress. Part Fibre Toxicol. 2022 Oct 14;19(1):64. doi: 10.1186/s12989-022-00505-7. PMID: 36242005; PMCID: PMC9569114.
  • Gohar EY, De Miguel C, Obi IE, Daugherty EM, Hyndman KA, Becker BK, Jin C, Sedaka R, Johnston JG, Liu P, Speed JS, Mitchell T, Kriegel AJ, Pollock JS, Pollock DM. Acclimation to a high-salt diet is sex dependent. J Am Heart Assoc. 2022 Mar; 11(5):e020450. doi: 10.1161/JAHA.120.020450. Epub 2022 Feb 22.
  • Green PA, George EM, Rosvall KA, Johnsen S, Nowicki S. Testosterone, signal coloration, and signal color perception in male zebra finch contests. Ethology. 2022 Feb;128(2):131-142. doi: 10.1111/eth.13247. Epub 2021 Nov 2. PMID: 35185233
  • Hall ME, Hall JE, Whelton PK. Epidemiology, Pathophysiology and Treatment of Hypertension. In: Fuster and Hurst's The Heart, 15th ed. Eds. V Fuster, J Narula, P Vaishnava, MB Leon, DJ Callans, JS Rumsfeld. McGraw-Hill Medical, New York. 2022. pp. 819-832.
  • Hall ME, Hall JE. Sex differences in hypertension: related to genes, jean sizes, and salt sensitivity? Hypertension. 2022. PMID: 34878896
  • Irazabal MV, Chade AR, Eirin A. Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs. Clin Sci (Lond). 2022 Mar 18;136(5):345-360. doi: 10.1042/CS20210512. PMID: 35260892; PMCID: PMC10018514.
  • Li X, Flynn ER, do Carmo JM, Wang Z, da Silva AA, Mouton AJ, Omoto ACM, Hall ME, Hall JE. Direct cardiac actions of sodium-glucose cotransporter 2 inhibition improve mitochondrial function and attenuate oxidative stress in pressure overload-induced heart failure. Front Cardiovasc Med. 2022 May 12;9:859253. doi: 10.3389/fcvm.2022.859253. PMID: 35647080
  • Lipshutz JA, Hall JE, Penman-Aguilar A, Skillen E, Naoom S. Irune I. Leveraging social and structural determinants of health at the centers for disease control and prevention: a systems-level opportunity to improve public health. J Public Health Manag Pract. 2022 Mar-Apr 01;28(2):E380-E389. doi: 10.1097/PHH.0000000000001363. PMID: 33938483
  • Liu J, Pan L, Hong W, Chen S, Bai P, Luo W, Sun X, He F, Jia X, Cai J, Chen Y, Hu K, Song Z, Ge J, Sun A. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Nat Commun. 2022 Dec 6;13(1):7519. doi: 10.1038/s41467-022-35159-8. PMID: 36473866; PMCID: PMC9727025.
  • Lu Y, Stec DE, Liu R, Ryan M, Drummond HA. βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole. Am J Physiol Renal Physiol. 2022 May 1;322(5):F498-F511. doi: 10.1152/ajprenal.00003.2022. Epub 2022 Mar 14. PMID: 35285274
  • McClung JA, Levy L, Garcia V, Stec DE, Peterson SJ, Abraham NG. Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: thereapeutic implications. Pharmacol Ther. 2022 Mar;231:107975. doi: 10.1016/j.pharmthera.2021.107975. Epub 2021 Sep 6. PMID: 35204062
  • Murphy J, Le TNV, Fedorova J, Yang Y, Krause-Hauch M, Davitt K, Zoungrana LI, Fatmi MK, Lesnefsky EJ, Li J, Ren D. The Cardiac Dysfunction Caused by Metabolic Alterations in Alzheimer's Disease. Front Cardiovasc Med. 2022 Feb 22;9:850538. doi: 10.3389/fcvm.2022.850538. PMID: 35274014; PMCID: PMC8902161.
  • Nemeth Z, Hildebrandt E, Parsa N, Fleming AB, Wasson R, Pittman K, Bell X, Granger JP, Ryan MJ, Drummond HA. Epithelial sodium channels in macrophage migration and polarization: role of proinflammatory cytokines TNFα and IFNγ. Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1;323(5):R763-R775. doi: 10.1152/ajpregu.00207.2022. Epub 2022 Oct 3. PMID: 36189990; PMCID: PMC9639769.
  • Nemeth, Zoltan; Granger, Joey P; Ryan, Michael J; Drummond, Heather A. Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia? Physiol Rep. 2022 Jul;10(13):e15376.doi: 10.14814/phy2.15376.
  • Omoto ACM, do Carmo JM, Nelson B, Aitken N, Dai X, Moak S, Flynn E, Wang Z, Mouton AJ, Li X, Hall JE, da Silva AA. Central nervous system actions of leptin improve cardiac function after ischemia-reperfusion: roles of sympathetic innervation and sex differences. J Am Heart Assoc. 2022 Nov;11(21):e027081. doi: 10.1161/JAHA.122.027081. Epub 2022 Oct 27. PMID: 36300667; PMCID: PMC9673649.
  • Oshunbade AA, Lirette ST, Windham BG, Shafi T, Hamid A, Gbadamosi SO, Tin A, Yimer WK, Tibuakuu M, Clark D 3rd, Kamimura D, Lutz EA, Mentz RJ, Fox ER, Butler J, Butler KR, Garovic VD, Turner ST, Mosley TH Jr, Hall ME. Hypertensice diseases in pregnancy and kidney function later in life: the genetic epidemiology network of arteriopathy (GENOA) study. Mayo Clin Proc. 2022 Jan;97(1):78-87. doi: 10.1016/j.mayocp.2021.07.018. PMID: 34565606
  • Pan L, Bai P, Weng X, Liu J, Chen Y, Chen S, Ma X, Hu K, Sun A, Ge J. Legumain is an endogenous modulator of integrin αvβ3 triggering vascular degeneration, dissection, and rupture. Circulation. 2022 Mar;145(9):659-674. PMID: 35100526.10.1161/CIRCULATIONAHA.121.056640.
  • Rajagopalan KS, Glasstetter LM, Zhy XY, Thaler R, Tang H, Jordan KL, Saadiq IM, Herrmann SM, Chade AR, Irazabal MV, Lerman LO. Renal ischemia induces epigenetic changes in apoptotic, proteolytic, and mitochondrial genes in swine scattered tubular-like cells. Cells. 2022 May 31;11(11):1803
  • Rhoads MK, Speed JS, Roth KJ, Zhang D, Jin C, Gamble KL, Pollock DM. Short-term daytime restricted feeding in rats with high salt impairs diurnal variation of Na+ excretion. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F335-F343
  • Rodionov RN, Jarzebska N, Burdin D, Todorov V, Martens-Lobenhoffer J, Hofmann A, Kolouschek A, Cordasic N, Jacobi J, Rubets E, Morawietz H, O'Sullivan JF, Markov AG, Bornstein SR, Hilgers K, Maas R, Pfluecke C, Chen Y, Bode-Böger SM, Hugo CPM, Hohenstein B, Weiss N. Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Sci Rep. 2022 Jun 7;12(1):9381. PMC9174227.10.1038/s41598-022-13169-2
  • Shawky NM, Dalmasso C, Ojeda NB, Zuckowski Y, Stachenfeld N, Alexander BT, Reckelhoff JF. Consequences of hyperandrogenemia during pregnancy in femail offspring: attenuated response to angiotensin II. J Hyperten. 2022 Apr 1;40(4):712-722. doi: 10.1097/HJH.0000000000003067. PMID: 34980865; PMCID: PMC8897268.
  • Stapel JR, Speed JS, Clemmer JS. Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension. Can J Physiol Pharmacol. 2022 Aug 1;100(8):828-833. doi: 10.1139/cjpp-2022-0132. Epub 2022 Jun 3.
  • Stec DE, Tiribelli C, Badmus OO, Hinds TD Jr.. Novel function for bilirubin as a metabolic signaling molecule: implications for kidney diseases. Kidney360. 2022 Mar 25;3(5):945-953. doi: 10.34067/KID.0000062022. PMID: 36128497; PMCID: PMC9438427.
  • Taylor EB, George EM. Animal Models of Preeclampsia: Mechanistic Insights and Promising Therapeutics. Endocrinology. 2022 Aug 1;163(8):bqac096. doi: 10.1210/endocr/bqac096. PMID: 35772781; PMCID: PMC9262036.
  • Thomas DT, DelCimmuto NR, Flack KD, Stec DE, Hinds TD Jr. Reactive oxygen species (ROS) and antioxidants as immunonomodulators in exercise: implications for heme oxygenase and bilirubin. Antioxidants (Basel). 2022 Jan 18;11(2):179. doi: 10.3390/antiox11020179 PMID: 35204062
  • Wang Z, Fu Y, Do Carmo JM, da Silva AA, Li X, Mouton A, Omoto ACM, Sears J, Hall JE. Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F76-F88.
  • Wang Z, do Carmo JM, da Silva AA, Fu Y, Jaynes LT, Sears J, Li X, Mouton AJ, Omoto ACM, Xu BP, Hall JE. Transient receptor potential cation channel 6 (TRPC6) deficiency leads to increased body weight and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2022 May 10. doi: 10.1152/ajpregu.00097.2021. Epub ahead of print. PMID: 35537100.
  • Yang J, Hall JE, Jose PA, Chen K, Zeng C. Comprehensive insights in GRK4 and hypertension: from mechanisms to potential therapeutics. Pharmacol Ther. 2022 Apr 26:108194. doi: 10.1016/j.pharmthera.2022.108194. PMID: 35487286
  • Zoungrana LI, Krause-Hauch M, Wang H, Fatmi MK, Bates L, Li Z, Kulkarni P, Ren D, Li J. The Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases. Cells. 2022 Jun 28;11(13):2048. doi: 10.3390/cells11132048. PMID: 35805130; PMCID: PMC9265429.